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FACTSHEET: LOGKOW Database
The LOGKOW Database eliminates tedious literature searching and reduces the time and cost of obtaining partition coefficient data. A partition or distribution coefficient is the equilibrium ratio of the concentration of a substance dissolved in an organic solvent to the concentration of the same substance dissolved in water. The octanol/water coefficient (logKow) is the standard system which relates to biological activity and the environmental impact of chemicals.
LOGKOW DATABASE contains:- over 30,000 critically evaluated octanol/water partition coefficients for over 23,000 organic compounds including many recommended values.
- over 1,984 current literature references in Chemical Abstracts style.
- Acid dissociation constants (pKa).
- Chemicals identified by CAS Registry Number, SMILES notation & molecular formula.
- Information about the pH, temperature, phases analyzed, nature of the aqueous phase, method and, method reference.
Substances in the database include:
| Drugs & pharmaceuticals | Environmental hazards |
| Herbicides, pesticides, fungicides | Acid-base addition compounds |
| Amino-acids & peptides | |
| Dyes, substituted phenols & other wastewater solutes | |
| PCB's (176 congeners), PAH's & other chlorinated compounds | |
| Poisons & toxins |
Who should use the LOGKOW DATABASE:
| Medicinal Chemists | Anal. Chemists | Pharmacologists |
| Environ. Engineers | Chemical Engineers | Toxicologists |
| Information Specialists |
Professionals in the design of - pharmaceuticals and medicinal chemicals; environmental impact analysis; risk assessment; toxicology; the prediction and correlation of thebioconcentration, soil and sediment absorption of organic pollutants; the solubility and modeling of the environmental fate of organic chemicals - will find this user-friendly databank extremely valuable. LogKow values are used in:
| Environmental Analysis | Hazard Assessment |
| Processes where chemico-biological interactions need to be modeled | |
| Drug Synthesis | Pesticide Design |
| Extraction procedures |
LOGKOW DATABASE can be searched by:
- CAS Registry Number.
- Molecular Formula.
- "Browse" Mode (partial molecular formula or name fragment).
- Range of values (find all chemicals in the database with a logKow measurement between specified limits).
LOGKOW DATABASE is developed and is maintained by Sangster Research Laboratories.